The use of celery seed in pills for relieving pain was described by Aulus Cornelius Celsus around AD 30. Celery seeds contain a compound, 3-n-butylphthalide, that has been demonstrated to lower blood pressure in rats. In a study recent to 2013, 30 patients suffering from mild to moderate hypertension were given celery seed extract at 150 mg per day. There were results showing a decrease in both systolic (SBP) and diastolic blood pressure.
Bergapten in the seeds can increase photosensitivity, so the use ofessential oil externally in bright sunshine should be avoided. The oil and large doses of seeds should be avoided during pregnancy, as they can act as a uterine stimulant. Seeds intended for cultivation are not suitable for eating as they are often treated with fungicides.
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